Fabrication and Characterization of Herbal Drug –Loaded Nonionic Surfactant Based Niosomal Topical Gel

The aim and objective of the study was to develop herbal drug loaded niosomes as topical gel by using thin film hydration technique. The practicability of herbal drug (CODE: THDC3-2615RD) of niosomes by thin film hydration technique using Span series 20, 60, 80 and cholesterol has been successfully revealed in this study. The evolved herbal niosomes were evaluated for morphology, particle size and in vitro release study. The optimized batch F7 (Span 60 C/S; 1.5:5) showed highest entrapment efficiency 97.12%, prolonged in vitro release of 81.56% and the stability studies showed good results at 4°±2°C. Niosomal gel was formulated by dispersing the optimized batch F7 into Carbopal 940 and HPMC. The in vitro release study was carried out for the plain herbal gel and niosomal herbal gel, in which the niosomal gel revealed better results. Furthermore ex vivo permeation study was carried out for the niosomal gel.